This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3low

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3low" [edit=sysop:move=sysop])
Current revision (08:46, 7 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3low.png|left|200px]]
 
-
{{STRUCTURE_3low| PDB=3low | SCENE= }}
+
==Crystal structure of Beta 2 Microglobulin domain-swapped dimer==
-
 
+
<StructureSection load='3low' size='340' side='right'caption='[[3low]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
===Crystal structure of Beta 2 Microglobulin domain-swapped dimer===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3low]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LOW FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_021131979}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3low FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3low OCA], [https://pdbe.org/3low PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3low RCSB], [https://www.ebi.ac.uk/pdbsum/3low PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3low ProSAT]</span></td></tr>
-
[[3low]] is a 2 chain structure of [[Beta-2 microglobulin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOW OCA].
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
==See Also==
==See Also==
-
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
+
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:021131979</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Eisenberg, D.]]
+
[[Category: Large Structures]]
-
[[Category: Liu, C.]]
+
[[Category: Eisenberg D]]
-
[[Category: Amyloidosis]]
+
[[Category: Liu C]]
-
[[Category: Beta sheet hinge region]]
+
-
[[Category: Domain-swap]]
+
-
[[Category: Inter-molecular disulfide bond]]
+
-
[[Category: Protein fibril]]
+

Current revision

Crystal structure of Beta 2 Microglobulin domain-swapped dimer

PDB ID 3low

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3low"
Personal tools