1pqk
From Proteopedia
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| - | [[Image:1pqk.png|left|200px]] | ||
| - | + | ==Repacking of the Core of T4 Lysozyme by Automated Design== | |
| - | + | <StructureSection load='1pqk' size='340' side='right'caption='[[1pqk]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1pqk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PQK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pqk OCA], [https://pdbe.org/1pqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pqk RCSB], [https://www.ebi.ac.uk/pdbsum/1pqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pqk ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1pqk]] is a 3 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pq/1pqk_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pqk ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Lysozyme 3D structures|Lysozyme 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Escherichia virus T4]] |
| - | [[Category: Baase | + | [[Category: Large Structures]] |
| - | [[Category: Datta | + | [[Category: Baase WA]] |
| - | [[Category: Matthews | + | [[Category: Datta D]] |
| - | [[Category: Mayo | + | [[Category: Matthews BW]] |
| - | [[Category: Mooers | + | [[Category: Mayo SL]] |
| - | [[Category: Zollars | + | [[Category: Mooers BH]] |
| - | + | [[Category: Zollars ES]] | |
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Current revision
Repacking of the Core of T4 Lysozyme by Automated Design
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