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1cz3

From Proteopedia

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[[Image:1cz3.png|left|200px]]
 
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{{STRUCTURE_1cz3| PDB=1cz3 | SCENE= }}
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==DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA==
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<StructureSection load='1cz3' size='340' side='right'caption='[[1cz3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1cz3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CZ3 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10731419}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cz3 OCA], [https://pdbe.org/1cz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cz3 RCSB], [https://www.ebi.ac.uk/pdbsum/1cz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cz3 ProSAT]</span></td></tr>
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[[1cz3]] is a 2 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZ3 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYR_THEMA DYR_THEMA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/1cz3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cz3 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Dihydrofolate reductase|Dihydrofolate reductase]]
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010731419</ref><ref group="xtra">PMID:011742118</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Auerbach, G.]]
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[[Category: Auerbach G]]
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[[Category: Bader, G.]]
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[[Category: Bader G]]
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[[Category: Dams, T.]]
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[[Category: Dams T]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Jaenicke, R.]]
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[[Category: Jaenicke R]]
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[[Category: Ploom, T.]]
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[[Category: Ploom T]]
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[[Category: Dimer]]
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[[Category: Hyperthermophile]]
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[[Category: Oxidoreductase]]
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Current revision

DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA

PDB ID 1cz3

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