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4rnp

From Proteopedia

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[[Image:4rnp.png|left|200px]]
 
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{{STRUCTURE_4rnp| PDB=4rnp | SCENE= }}
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==BACTERIOPHAGE T7 RNA POLYMERASE, HIGH SALT CRYSTAL FORM, LOW TEMPERATURE DATA, ALPHA-CARBONS ONLY==
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<StructureSection load='4rnp' size='340' side='right'caption='[[4rnp]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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===BACTERIOPHAGE T7 RNA POLYMERASE, HIGH SALT CRYSTAL FORM, LOW TEMPERATURE DATA, ALPHA-CARBONS ONLY===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4rnp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_T7 Escherichia phage T7]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3rnp 3rnp] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2rnp 2rnp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RNP FirstGlance]. <br>
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{{ABSTRACT_PUBMED_7688864}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rnp OCA], [https://pdbe.org/4rnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rnp RCSB], [https://www.ebi.ac.uk/pdbsum/4rnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rnp ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[4rnp]] is a 3 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t7 Enterobacteria phage t7]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2rnp 2rnp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RNP OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/RPOL_BPT7 RPOL_BPT7] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Responsible for the transcription of the late genes of T7. It is rifampicin-resistant. It recognizes a specific promoter sequence, unwinds the double-stranded RNA to expose the coding strand for templating, initiates transcription preferentially with a purine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/4rnp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4rnp ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:007688864</ref><references group="xtra"/>
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[[Category: Escherichia phage T7]]
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Large Structures]]
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[[Category: Enterobacteria phage t7]]
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[[Category: Liu ZJ]]
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[[Category: Liu, Z J.]]
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[[Category: Rose JP]]
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[[Category: Rose, J P.]]
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[[Category: Sousa R]]
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[[Category: Sousa, R.]]
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[[Category: Wang BC]]
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[[Category: Wang, B C.]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Rna polymerase]]
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[[Category: Transcription]]
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Current revision

BACTERIOPHAGE T7 RNA POLYMERASE, HIGH SALT CRYSTAL FORM, LOW TEMPERATURE DATA, ALPHA-CARBONS ONLY

PDB ID 4rnp

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