1yrk

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[[Image:1yrk.png|left|200px]]
 
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{{STRUCTURE_1yrk| PDB=1yrk | SCENE= }}
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==The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain==
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<StructureSection load='1yrk' size='340' side='right'caption='[[1yrk]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yrk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YRK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yrk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yrk OCA], [https://pdbe.org/1yrk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yrk RCSB], [https://www.ebi.ac.uk/pdbsum/1yrk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yrk ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yr/1yrk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yrk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a phosphotyrosine binding domain and present the crystal structure of this C2 domain bound to a peptide containing phosphotyrosine. Prior to this work, C2 domains were thought to bind only to phospholipids or to unphosphorylated proteins, and the SH2 and PTB domains were the only signaling domains known to recognize phosphotyrosine. This new role for the C2 domain links phosphotyrosine recognition directly to serine/threonine kinase activity and reveals an unexpected mechanism for crosstalk between distinct signaling pathways.
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===The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain===
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C2 can do it, too.,Sondermann H, Kuriyan J Cell. 2005 Apr 22;121(2):158-60. PMID:15851022<ref>PMID:15851022</ref>
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{{ABSTRACT_PUBMED_15851022}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1yrk" style="background-color:#fffaf0;"></div>
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[[1yrk]] is a 2 chain structure of [[Protein kinase C]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRK OCA].
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==See Also==
==See Also==
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*[[Protein kinase C|Protein kinase C]]
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*[[Protein kinase C 3D structures|Protein kinase C 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015851022</ref><ref group="xtra">PMID:015851033</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Benes, C H.]]
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[[Category: Large Structures]]
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[[Category: Cantley, L C.]]
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[[Category: Benes CH]]
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[[Category: Dharia, T.]]
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[[Category: Cantley LC]]
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[[Category: Elia, A E.]]
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[[Category: Dharia T]]
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[[Category: Soltoff, S P.]]
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[[Category: Elia AE]]
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[[Category: Wu, N.]]
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[[Category: Soltoff SP]]
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[[Category: C2 domain]]
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[[Category: Wu N]]
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[[Category: Protein binding]]
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Current revision

The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain

PDB ID 1yrk

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