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2ii5

From Proteopedia

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[[Image:2ii5.png|left|200px]]
 
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{{STRUCTURE_2ii5| PDB=2ii5 | SCENE= }}
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==Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (E2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), Isobutyryl-Coenzyme A-bound form==
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<StructureSection load='2ii5' size='340' side='right'caption='[[2ii5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (E2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), Isobutyryl-Coenzyme A-bound form===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ii5]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2II5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2II5 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17124494}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO6:ISOBUTYRYL-COENZYME+A'>CO6</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ii5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ii5 OCA], [https://pdbe.org/2ii5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ii5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ii5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ii5 ProSAT]</span></td></tr>
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[[2ii5]] is a 8 chain structure of [[Dihydrolipoamide dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2II5 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ODB2_BOVIN ODB2_BOVIN] The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/2ii5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ii5 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Dihydrolipoamide dehydrogenase|Dihydrolipoamide dehydrogenase]]
*[[Dihydrolipoamide dehydrogenase|Dihydrolipoamide dehydrogenase]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017124494</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Brautigam, C A.]]
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[[Category: Large Structures]]
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[[Category: Chuang, D T.]]
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[[Category: Brautigam CA]]
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[[Category: Chuang, J L.]]
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[[Category: Chuang DT]]
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[[Category: Custorio, M.]]
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[[Category: Chuang JL]]
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[[Category: Kato, M.]]
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[[Category: Custorio M]]
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[[Category: Wynn, R M.]]
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[[Category: Kato M]]
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[[Category: Cubic core]]
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[[Category: Wynn RM]]
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[[Category: Homo trimer]]
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[[Category: Isobutyryl-coa-bound form]]
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[[Category: Transferase]]
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Current revision

Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (E2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), Isobutyryl-Coenzyme A-bound form

PDB ID 2ii5

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OCA

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