3q8s

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[[Image:3q8s.png|left|200px]]
 
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{{STRUCTURE_3q8s| PDB=3q8s | SCENE= }}
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==Human DNA polymerase iota incorporating dTTP opposite 8-oxo-guanine==
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<StructureSection load='3q8s' size='340' side='right'caption='[[3q8s]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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===Human DNA polymerase iota incorporating dTTP opposite 8-oxo-guanine===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3q8s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q8S FirstGlance]. <br>
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{{ABSTRACT_PUBMED_021300901}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q8s OCA], [https://pdbe.org/3q8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q8s RCSB], [https://www.ebi.ac.uk/pdbsum/3q8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q8s ProSAT]</span></td></tr>
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[[3q8s]] is a 3 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q8S OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POLI_HUMAN POLI_HUMAN] Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.<ref>PMID:11013228</ref> <ref>PMID:11251121</ref> <ref>PMID:11387224</ref> <ref>PMID:12410315</ref> <ref>PMID:14630940</ref> <ref>PMID:15199127</ref> <ref>PMID:15254543</ref>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021300901</ref><references group="xtra"/>
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__TOC__
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[[Category: DNA-directed DNA polymerase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kirouac, K N.]]
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[[Category: Large Structures]]
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[[Category: Ling, H.]]
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[[Category: Synthetic construct]]
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[[Category: Dna polymerase]]
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[[Category: Kirouac KN]]
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[[Category: Transferase-dna complex]]
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[[Category: Ling H]]

Current revision

Human DNA polymerase iota incorporating dTTP opposite 8-oxo-guanine

PDB ID 3q8s

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