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2dhn

From Proteopedia

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[[Image:2dhn.png|left|200px]]
 
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{{STRUCTURE_2dhn| PDB=2dhn | SCENE= }}
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==COMPLEX OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 2.2 A RESOLUTION==
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<StructureSection load='2dhn' size='340' side='right'caption='[[2dhn]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===COMPLEX OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 2.2 A RESOLUTION===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2dhn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DHN FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9586996}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PH2:2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE'>PH2</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhn OCA], [https://pdbe.org/2dhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dhn RCSB], [https://www.ebi.ac.uk/pdbsum/2dhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dhn ProSAT]</span></td></tr>
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[[2dhn]] is a 1 chain structure of [[Aldolase]] with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHN OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FOLB_STAAU FOLB_STAAU] Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/2dhn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dhn ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aldolase|Aldolase]]
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*[[Aldolase 3D structures|Aldolase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:009586996</ref><ref group="xtra">PMID:010737935</ref><ref group="xtra">PMID:017530916</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Arcy, A D.]]
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[[Category: D'Arcy A]]
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[[Category: Dale, G.]]
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[[Category: Dale G]]
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[[Category: Hampele, I C.]]
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[[Category: Hampele IC]]
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[[Category: Hennig, M.]]
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[[Category: Hennig M]]
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[[Category: Oefner, C H.]]
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[[Category: Oefner CH]]
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[[Category: Page, M G.P.]]
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[[Category: Page MGP]]
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[[Category: Antibiotic target]]
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[[Category: Beta-barrel]]
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[[Category: Folate biosynthesis]]
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[[Category: Product complex]]
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[[Category: Pterine binding]]
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Current revision

COMPLEX OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 2.2 A RESOLUTION

PDB ID 2dhn

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