1a8h

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[[Image:1a8h.png|left|200px]]
 
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{{STRUCTURE_1a8h| PDB=1a8h | SCENE= }}
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==METHIONYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS==
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<StructureSection load='1a8h' size='340' side='right'caption='[[1a8h]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===METHIONYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1a8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8H FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10673435}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8h OCA], [https://pdbe.org/1a8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8h RCSB], [https://www.ebi.ac.uk/pdbsum/1a8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8h ProSAT], [https://www.topsan.org/Proteins/RSGI/1a8h TOPSAN]</span></td></tr>
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[[1a8h]] is a 1 chain structure of [[Aminoacyl tRNA Synthetase]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8H OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYM_THET8 SYM_THET8] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8h ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010673435</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Methionine--tRNA ligase]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Thermus thermophilus]]
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[[Category: Giege R]]
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[[Category: Giege, R.]]
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[[Category: Konno M]]
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[[Category: Konno, M.]]
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[[Category: Kuwabara S]]
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[[Category: Kuwabara, S.]]
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[[Category: Lober B]]
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[[Category: Lober, B.]]
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[[Category: Moras D]]
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[[Category: Moras, D.]]
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[[Category: Nureki O]]
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[[Category: Nureki, O.]]
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[[Category: Sugiura I]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Ugaji Y]]
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[[Category: Sugiura, I.]]
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[[Category: Yokoyama S]]
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[[Category: Ugaji, Y.]]
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[[Category: Yokoyama, S.]]
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[[Category: Aminoacyl-trna synthetase]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rossmann fold]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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Current revision

METHIONYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS

PDB ID 1a8h

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