1df1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:53, 7 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1df1.png|left|200px]]
 
-
{{STRUCTURE_1df1| PDB=1df1 | SCENE= }}
+
==MURINE INOSOXY DIMER WITH ISOTHIOUREA BOUND IN THE ACTIVE SITE==
-
 
+
<StructureSection load='1df1' size='340' side='right'caption='[[1df1]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-
===MURINE INOSOXY DIMER WITH ISOTHIOUREA BOUND IN THE ACTIVE SITE===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1df1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DF1 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_10562539}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ITU:ETHYLISOTHIOUREA'>ITU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1df1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1df1 OCA], [https://pdbe.org/1df1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1df1 RCSB], [https://www.ebi.ac.uk/pdbsum/1df1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1df1 ProSAT]</span></td></tr>
-
[[1df1]] is a 2 chain structure of [[Nitric Oxide Synthase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DF1 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/df/1df1_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1df1 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Nitric Oxide Synthase|Nitric Oxide Synthase]]
+
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:010562539</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Nitric-oxide synthase]]
+
[[Category: Arvai AS]]
-
[[Category: Arvai, A S.]]
+
[[Category: Crane BR]]
-
[[Category: Crane, B R.]]
+
[[Category: Getzoff ED]]
-
[[Category: Getzoff, E D.]]
+
[[Category: Ghosh DK]]
-
[[Category: Ghosh, D K.]]
+
[[Category: Ghosh S]]
-
[[Category: Ghosh, S.]]
+
[[Category: Rosenfeld RJ]]
-
[[Category: Rosenfeld, R J.]]
+
[[Category: Stuehr DJ]]
-
[[Category: Stuehr, D J.]]
+
[[Category: Tainer JA]]
-
[[Category: Tainer, J A.]]
+
-
[[Category: Heme]]
+
-
[[Category: Ino]]
+
-
[[Category: Isothiourea]]
+
-
[[Category: Nitric oxide l-arginine monooxygenase]]
+
-
[[Category: No]]
+
-
[[Category: Oxidoreductase]]
+

Current revision

MURINE INOSOXY DIMER WITH ISOTHIOUREA BOUND IN THE ACTIVE SITE

PDB ID 1df1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1df1"
Personal tools