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3tz3
From Proteopedia
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| - | [[Image:3tz3.png|left|200px]] | ||
| - | + | ==Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 2== | |
| - | + | <StructureSection load='3tz3' size='340' side='right'caption='[[3tz3]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3tz3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZ3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B36:6-{[1-(ANTHRACEN-9-YLCARBONYL)PIPERIDIN-4-YL]METHYL}-2-METHYLQUINOLINE'>B36</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tz3 OCA], [https://pdbe.org/3tz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tz3 RCSB], [https://www.ebi.ac.uk/pdbsum/3tz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tz3 ProSAT]</span></td></tr> |
| - | [[3tz3]] | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACAC_YEAST ACAC_YEAST] Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.<ref>PMID:6108218</ref> <ref>PMID:6103540</ref> <ref>PMID:8943372</ref> <ref>PMID:10757783</ref> <ref>PMID:12730220</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Acetyl-CoA carboxylase|Acetyl-CoA carboxylase]] | + | *[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]] |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | < | + | </StructureSection> |
| - | [[Category: Saccharomyces cerevisiae | + | [[Category: Large Structures]] |
| - | [[Category: Anderson | + | [[Category: Saccharomyces cerevisiae S288C]] |
| - | [[Category: Corbett | + | [[Category: Anderson MD]] |
| - | [[Category: Dirico | + | [[Category: Corbett JW]] |
| - | [[Category: Harwood | + | [[Category: Dirico KJ]] |
| - | [[Category: Landro | + | [[Category: Harwood JH]] |
| - | [[Category: Marr | + | [[Category: Landro JA]] |
| - | [[Category: Rajamohan | + | [[Category: Marr E]] |
| - | [[Category: Reyes | + | [[Category: Rajamohan F]] |
| - | [[Category: Tu | + | [[Category: Reyes A]] |
| - | [[Category: Vajdos | + | [[Category: Tu M]] |
| - | + | [[Category: Vajdos FF]] | |
| - | + | ||
Current revision
Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 2
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