3m91

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[[Image:3m91.png|left|200px]]
 
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{{STRUCTURE_3m91| PDB=3m91 | SCENE= }}
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==Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa==
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<StructureSection load='3m91' size='340' side='right'caption='[[3m91]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3m91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M91 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20953180}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m91 OCA], [https://pdbe.org/3m91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m91 RCSB], [https://www.ebi.ac.uk/pdbsum/3m91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m91 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3m91]] is a 4 chain structure of [[ATPase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M91 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/ARC_MYCTU ARC_MYCTU] ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Is required but not sufficient to confer resistance against the lethal effects of reactive nitrogen intermediates (RNI), antimicrobial molecules produced by activated macrophages and other cell types.[HAMAP-Rule:MF_02112]<ref>PMID:14671303</ref> <ref>PMID:15659170</ref> <ref>PMID:17082771</ref> <ref>PMID:19836337</ref> <ref>PMID:20203624</ref>
==See Also==
==See Also==
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*[[ATPase|ATPase]]
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*[[ATPase 3D structures|ATPase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020953180</ref><references group="xtra"/>
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__TOC__
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[[Category: Mycobacterium tuberculosis]]
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</StructureSection>
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[[Category: Li, H.]]
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[[Category: Large Structures]]
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[[Category: Wang, T.]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Atp-binding]]
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[[Category: Li H]]
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[[Category: Chaperone]]
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[[Category: Wang T]]
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[[Category: Coil coil alpha helix]]
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[[Category: Hydrolase regulator]]
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[[Category: Isopeptide bond]]
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[[Category: Nucleotide-binding]]
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[[Category: Proteasome]]
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[[Category: S-nitrosylation]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Virulence]]
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Current revision

Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa

PDB ID 3m91

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