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1nez

From Proteopedia

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[[Image:1nez.png|left|200px]]
 
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{{STRUCTURE_1nez| PDB=1nez | SCENE= }}
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==The Crystal Structure of a TL/CD8aa Complex at 2.1A resolution:Implications for Memory T cell Generation, Co-receptor Preference and Affinity==
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<StructureSection load='1nez' size='340' side='right'caption='[[1nez]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===The Crystal Structure of a TL/CD8aa Complex at 2.1A resolution:Implications for Memory T cell Generation, Co-receptor Preference and Affinity===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nez]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NEZ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12594948}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nez OCA], [https://pdbe.org/1nez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nez RCSB], [https://www.ebi.ac.uk/pdbsum/1nez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nez ProSAT]</span></td></tr>
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[[1nez]] is a 4 chain structure of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEZ OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HA1T_MOUSE HA1T_MOUSE] Involved in the presentation of foreign antigens to the immune system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ne/1nez_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nez ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Beta-2 microglobulin|Beta-2 microglobulin]]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[Major histocompatibility complex|Major histocompatibility complex]]
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*[[CD8 3D structures|CD8 3D structures]]
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*[[MHC 3D structures|MHC 3D structures]]
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==Reference==
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*[[MHC I 3D structures|MHC I 3D structures]]
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<ref group="xtra">PMID:012594948</ref><references group="xtra"/>
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__TOC__
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[[Category: Cheroutre, H.]]
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</StructureSection>
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[[Category: Joachimiak, A.]]
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[[Category: Large Structures]]
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[[Category: Kronenberg, M.]]
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[[Category: Mus musculus]]
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[[Category: Liu, J H.]]
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[[Category: Cheroutre H]]
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[[Category: Liu, Y.]]
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[[Category: Joachimiak A]]
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[[Category: Naidenko, O V.]]
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[[Category: Kronenberg M]]
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[[Category: Reinherz, E L.]]
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[[Category: Liu JH]]
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[[Category: Wang, J H.]]
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[[Category: Liu Y]]
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[[Category: Xiong, Y.]]
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[[Category: Naidenko OV]]
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[[Category: Zhang, R.]]
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[[Category: Reinherz EL]]
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[[Category: Immune system]]
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[[Category: Wang JH]]
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[[Category: Xiong Y]]
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[[Category: Zhang R]]

Current revision

The Crystal Structure of a TL/CD8aa Complex at 2.1A resolution:Implications for Memory T cell Generation, Co-receptor Preference and Affinity

PDB ID 1nez

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