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1l8o

From Proteopedia

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[[Image:1l8o.png|left|200px]]
 
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{{STRUCTURE_1l8o| PDB=1l8o | SCENE= }}
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==Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase==
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<StructureSection load='1l8o' size='340' side='right'caption='[[1l8o]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1l8o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L8O FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12213811}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8o OCA], [https://pdbe.org/1l8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l8o RCSB], [https://www.ebi.ac.uk/pdbsum/1l8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8o ProSAT]</span></td></tr>
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[[1l8o]] is a 2 chain structure of [[Phosphoserine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8O OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN] Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:[https://omim.org/entry/614023 614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.<ref>PMID:14673469</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN] Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.<ref>PMID:12777757</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l8o ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Phosphoserine phosphatase|Phosphoserine phosphatase]]
*[[Phosphoserine phosphatase|Phosphoserine phosphatase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012213811</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoserine phosphatase]]
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[[Category: Large Structures]]
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[[Category: Heo, Y S.]]
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[[Category: Heo YS]]
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[[Category: Hwang, K Y.]]
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[[Category: Hwang KY]]
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[[Category: Jeon, Y H.]]
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[[Category: Jeon YH]]
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[[Category: Kim, H Y.]]
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[[Category: Kim HY]]
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[[Category: Kim, J H.]]
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[[Category: Kim JH]]
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[[Category: Lee, T G.]]
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[[Category: Lee TG]]
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[[Category: Moon, J.]]
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[[Category: Moon J]]
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[[Category: Park, M H.]]
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[[Category: Park MH]]
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[[Category: Park, S Y.]]
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[[Category: Park SY]]
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[[Category: Ro, S.]]
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[[Category: Ro S]]
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[[Category: Conformational rearrangement]]
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[[Category: Hydrolase]]
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[[Category: Phosphatase]]
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Current revision

Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase

PDB ID 1l8o

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