3q2h

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[[Image:3q2h.png|left|200px]]
 
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{{STRUCTURE_3q2h| PDB=3q2h | SCENE= }}
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==Adamts1 in complex with N-hydroxyformamide inhibitors of ADAM-TS4==
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<StructureSection load='3q2h' size='340' side='right'caption='[[3q2h]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3q2h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=QHF:N-[(2S,4S)-1-({4-[2-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)ETHYL]PIPERIDIN-1-YL}SULFONYL)-4-(5-FLUOROPYRIMIDIN-2-YL)-2-METHYLPENTAN-2-YL]-N-HYDROXYFORMAMIDE'>QHF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2h OCA], [https://pdbe.org/3q2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2h RCSB], [https://www.ebi.ac.uk/pdbsum/3q2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATS1_HUMAN ATS1_HUMAN] Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.<ref>PMID:10438512</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Two series of N-hydroxyformamide inhibitors of ADAM-TS4 were identified from screening compounds previously synthesised as inhibitors of matrix metalloproteinase-13 (collagenase-3). Understanding of the binding mode of this class of compound using ADAM-TS1 as a structural surrogate has led to the discovery of potent and very selective inhibitors with favourable DMPK properties. Synthesis, structure-activity relationships, and strategies to improve selectivity and lower in vivo metabolic clearance are described.
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===Adamts1 in complex with N-hydroxyformamide inhibitors of ADAM-TS4===
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The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis.,De Savi C, Pape A, Cumming JG, Ting A, Smith PD, Burrows JN, Mills M, Davies C, Lamont S, Milne D, Cook C, Moore P, Sawyer Y, Gerhardt S Bioorg Med Chem Lett. 2011 Mar 1;21(5):1376-81. Epub 2011 Jan 18. PMID:21300546<ref>PMID:21300546</ref>
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{{ABSTRACT_PUBMED_21300546}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3q2h" style="background-color:#fffaf0;"></div>
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[[3q2h]] is a 2 chain structure of [[A Disintegrin And Metalloproteinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2H OCA].
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==See Also==
==See Also==
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*[[A Disintegrin And Metalloproteinase|A Disintegrin And Metalloproteinase]]
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*[[A Disintegrin And Metalloproteinase 3D structures|A Disintegrin And Metalloproteinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021300546</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Gerhardt, S.]]
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[[Category: Large Structures]]
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[[Category: Hargreaves, D.]]
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[[Category: Gerhardt S]]
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[[Category: Adamts1 zn-metalloprotease]]
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[[Category: Hargreaves D]]
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[[Category: Disintegrin]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Metalloproteinase]]
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[[Category: Thrombospondin motif]]
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Current revision

Adamts1 in complex with N-hydroxyformamide inhibitors of ADAM-TS4

PDB ID 3q2h

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