2yks
From Proteopedia
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| - | [[Image:2yks.png|left|200px]] | ||
| - | + | ==PENTAMERIC LIGAND GATED ION CHANNEL ELIC MUTANT F246A== | |
| + | <StructureSection load='2yks' size='340' side='right'caption='[[2yks]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2yks]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Dickeya_chrysanthemi Dickeya chrysanthemi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YKS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yks OCA], [https://pdbe.org/2yks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yks RCSB], [https://www.ebi.ac.uk/pdbsum/2yks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yks ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ELIC_DICCH ELIC_DICCH] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | While the pentameric ligand-gated ion channel ELIC has recently provided first insight into the architecture of the family at high resolution, its detailed investigation was so far prevented by the fact that activating ligands were unknown. Here we describe a study on the functional characterization of ELIC by electrophysiology and X-ray crystallography. ELIC is activated by a class of primary amines that include the neurotransmitter GABA at high micro- to millimolar concentrations. The ligands bind to a conserved site and evoke currents that slowly desensitize over time. The protein forms cation selective channels with properties that resemble the nicotinic acetylcholine receptor. The high single channel conductance and the comparably simple functional behavior make ELIC an attractive model system to study general mechanisms of ion conduction and gating in this important family of neurotransmitter receptors. | ||
| - | + | Ligand activation of the prokaryotic pentameric ligand-gated ion channel ELIC.,Zimmermann I, Dutzler R PLoS Biol. 2011 Jun;9(6):e1001101. Epub 2011 Jun 21. PMID:21713033<ref>PMID:21713033</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2yks" style="background-color:#fffaf0;"></div> | |
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==See Also== | ==See Also== | ||
| - | *[[Ion channels|Ion channels]] | + | *[[Ion channels 3D structures|Ion channels 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Dickeya chrysanthemi]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Dutzler R]] |
| - | + | [[Category: Zimmermann I]] | |
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Current revision
PENTAMERIC LIGAND GATED ION CHANNEL ELIC MUTANT F246A
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