1evi

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[[Image:1evi.png|left|200px]]
 
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{{STRUCTURE_1evi| PDB=1evi | SCENE= }}
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==THREE-DIMENSIONAL STRUCTURE OF THE PURPLE INTERMEDIATE OF PORCINE KIDNEY D-AMINO ACID OXIDASE==
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<StructureSection load='1evi' size='340' side='right'caption='[[1evi]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===THREE-DIMENSIONAL STRUCTURE OF THE PURPLE INTERMEDIATE OF PORCINE KIDNEY D-AMINO ACID OXIDASE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1evi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EVI FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10876160}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PC:3,4-DIHYDRO-2H-PYRROLIUM-5-CARBOXYLATE'>2PC</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1evi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1evi OCA], [https://pdbe.org/1evi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1evi RCSB], [https://www.ebi.ac.uk/pdbsum/1evi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1evi ProSAT]</span></td></tr>
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[[1evi]] is a 2 chain structure of [[Amino acid oxidase]] with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVI OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OXDA_PIG OXDA_PIG] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ev/1evi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1evi ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Amino acid oxidase|Amino acid oxidase]]
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*[[Amino acid oxidase 3D structures|Amino acid oxidase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010876160</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: D-amino-acid oxidase]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Hirotsu, K.]]
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[[Category: Hirotsu K]]
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[[Category: Miura, R.]]
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[[Category: Miura R]]
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[[Category: Miyahara, I.]]
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[[Category: Miyahara I]]
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[[Category: Mizutani, H.]]
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[[Category: Mizutani H]]
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[[Category: Nishina, Y.]]
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[[Category: Nishina Y]]
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[[Category: Setoyama, C.]]
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[[Category: Setoyama C]]
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[[Category: Shiga, K.]]
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[[Category: Shiga K]]
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[[Category: Flavoenzyme]]
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[[Category: Oxidoreductase]]
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Current revision

THREE-DIMENSIONAL STRUCTURE OF THE PURPLE INTERMEDIATE OF PORCINE KIDNEY D-AMINO ACID OXIDASE

PDB ID 1evi

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