1ycq
From Proteopedia
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| - | [[Image:1ycq.png|left|200px]] | ||
| - | + | ==XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53== | |
| - | + | <StructureSection load='1ycq' size='340' side='right'caption='[[1ycq]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1ycq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The July 2002 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''p53 Tumor Suppressor'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2002_7 10.2210/rcsb_pdb/mom_2002_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YCQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ycq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ycq OCA], [https://pdbe.org/1ycq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ycq RCSB], [https://www.ebi.ac.uk/pdbsum/1ycq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ycq ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1ycq]] | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yc/1ycq_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ycq ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[MDM2|MDM2]] | *[[MDM2|MDM2]] | ||
| - | *[[P53|P53]] | + | *[[MDM2 3D structures|MDM2 3D structures]] |
| - | + | *[[P53 3D structures|P53 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Xenopus laevis]] | [[Category: Xenopus laevis]] | ||
[[Category: P53 Tumor Suppressor]] | [[Category: P53 Tumor Suppressor]] | ||
| - | [[Category: Kussie | + | [[Category: Kussie PH]] |
| - | [[Category: Pavletich | + | [[Category: Pavletich NP]] |
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Current revision
XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53
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