1bih

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:33, 13 March 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1bih.gif|left|200px]]<br /><applet load="1bih" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1bih, resolution 3.10&Aring;" />
 
-
'''CRYSTAL STRUCTURE OF THE INSECT IMMUNE PROTEIN HEMOLIN: A NEW DOMAIN ARRANGEMENT WITH IMPLICATIONS FOR HOMOPHILIC ADHESION'''<br />
 
-
==Overview==
+
==CRYSTAL STRUCTURE OF THE INSECT IMMUNE PROTEIN HEMOLIN: A NEW DOMAIN ARRANGEMENT WITH IMPLICATIONS FOR HOMOPHILIC ADHESION==
-
Hemolin, an insect immunoglobulin superfamily member, is a lipopolysaccharide-binding immune protein induced during bacterial infection. The 3.1 angstrom crystal structure reveals a bound phosphate and patches of positive charge, which may represent the lipopolysaccharide binding site, and a new and unexpected arrangement of four immunoglobulin-like domains forming a horseshoe. Sequence analysis and analytical ultracentrifugation suggest that the domain arrangement is a feature of the L1 family of neural cell adhesion molecules related to hemolin. These results are relevant to interpretation of human L1 mutations in neurological diseases and suggest a domain swapping model for how L1 family proteins mediate homophilic adhesion.
+
<StructureSection load='1bih' size='340' side='right'caption='[[1bih]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1bih]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hyalophora_cecropia Hyalophora cecropia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BIH FirstGlance]. <br>
-
1BIH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hyalophora_cecropia Hyalophora cecropia] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BIH OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bih OCA], [https://pdbe.org/1bih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bih RCSB], [https://www.ebi.ac.uk/pdbsum/1bih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bih ProSAT]</span></td></tr>
-
Crystal structure of hemolin: a horseshoe shape with implications for homophilic adhesion., Su XD, Gastinel LN, Vaughn DE, Faye I, Poon P, Bjorkman PJ, Science. 1998 Aug 14;281(5379):991-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9703515 9703515]
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HEMO_HYACE HEMO_HYACE] Insect-immune protein. Forms a protein complex at the bacterial surface. Can inhibit hemocyte aggregation.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/1bih_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bih ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Hyalophora cecropia]]
[[Category: Hyalophora cecropia]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Bjorkman, P J.]]
+
[[Category: Bjorkman PJ]]
-
[[Category: Faye, I.]]
+
[[Category: Faye I]]
-
[[Category: Gastinel, L N.]]
+
[[Category: Gastinel LN]]
-
[[Category: Poon, P.]]
+
[[Category: Poon P]]
-
[[Category: Su, X D.]]
+
[[Category: Su X-D]]
-
[[Category: Vaughn, D E.]]
+
[[Category: Vaughn DE]]
-
[[Category: PO4]]
+
-
[[Category: homophilic adhesion]]
+
-
[[Category: insect immunity]]
+
-
[[Category: lps-binding]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:55:39 2008''
+

Current revision

CRYSTAL STRUCTURE OF THE INSECT IMMUNE PROTEIN HEMOLIN: A NEW DOMAIN ARRANGEMENT WITH IMPLICATIONS FOR HOMOPHILIC ADHESION

PDB ID 1bih

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bih"
Personal tools