3ef9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3ef9" [edit=sysop:move=sysop])
Current revision (09:47, 21 February 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3ef9.png|left|200px]]
 
-
{{STRUCTURE_3ef9| PDB=3ef9 | SCENE= }}
+
==Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability==
-
 
+
<StructureSection load='3ef9' size='340' side='right'caption='[[3ef9]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-
===Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3ef9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EF9 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_20151707}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ef9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ef9 OCA], [https://pdbe.org/3ef9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ef9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ef9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ef9 ProSAT]</span></td></tr>
-
[[3ef9]] is a 1 chain structure of [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EF9 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/3ef9_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ef9 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Thymidylate synthase|Thymidylate synthase]]
+
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:020151707</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Thymidylate synthase]]
+
[[Category: Large Structures]]
-
[[Category: Bell, B J.]]
+
[[Category: Bell BJ]]
-
[[Category: Berger, F G.]]
+
[[Category: Berger FG]]
-
[[Category: Berger, S H.]]
+
[[Category: Berger SH]]
-
[[Category: Gibson, L M.]]
+
[[Category: Gibson LM]]
-
[[Category: Huang, X.]]
+
[[Category: Huang X]]
-
[[Category: Lovelace, L L.]]
+
[[Category: Lovelace LL]]
-
[[Category: Pena, M M.]]
+
[[Category: Pena MM]]
-
[[Category: Methyltransferase]]
+
-
[[Category: Nucleotide biosynthesis]]
+
-
[[Category: Transferase]]
+

Current revision

Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability

PDB ID 3ef9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ef9"
Personal tools