1cg8

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[[Image:1cg8.png|left|200px]]
 
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{{STRUCTURE_1cg8| PDB=1cg8 | SCENE= }}
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==CO Form Hemoglobin from Dasyatis Akajei==
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<StructureSection load='1cg8' size='340' side='right'caption='[[1cg8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1cg8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hemitrygon_akajei Hemitrygon akajei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CG8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cg8 OCA], [https://pdbe.org/1cg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cg8 RCSB], [https://www.ebi.ac.uk/pdbsum/1cg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cg8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HBA_HEMAK HBA_HEMAK]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/1cg8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cg8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structures of the deoxy- and carbonmonoxyhaemoglobin (Hb) from Dasyatis akajei, a stingray, have been determined at 1.6 and 1.9 A resolution, respectively. This is one of the most distantly related vertebrate Hbs to human HbA. Both structures resemble the respective forms of HbA, indicating that the alpha2beta2-type tetramer and the mode of the quaternary structure change are common to Hbs of jawed vertebrates. Larger deviations between D. akajei Hb and human HbA are observed in various parts of the molecule, even in the E and F helices. Significant mutations and/or conformational changes are also observed around the haems, in the C-terminal region of the beta subunit, in the alpha1beta2 interface and in the organic phosphate-binding site of HbA. Despite these structural differences, the oxygen affinity, haem-haem interaction, Bohr effect and organic phosphate effect of D. akajei Hb are all only moderately reduced. Compared with human HbA, the overall r.m.s. deviation of main-chain atoms in the helical regions of bony fish Hbs is smaller than that of D. akajei Hb.
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===CO Form Hemoglobin from Dasyatis Akajei===
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Structures of the deoxy and CO forms of haemoglobin from Dasyatis akajei, a cartilaginous fish.,Chong KT, Miyazaki G, Morimoto H, Oda Y, Park SY Acta Crystallogr D Biol Crystallogr. 1999 Jul;55(Pt 7):1291-300. PMID:10393295<ref>PMID:10393295</ref>
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{{ABSTRACT_PUBMED_10393295}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1cg8" style="background-color:#fffaf0;"></div>
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[[1cg8]] is a 2 chain structure of [[Hemoglobin]] with sequence from [http://en.wikipedia.org/wiki/Dasyatis_akajei Dasyatis akajei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CG8 OCA].
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==See Also==
==See Also==
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*[[Hemoglobin|Hemoglobin]]
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010393295</ref><references group="xtra"/>
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__TOC__
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[[Category: Dasyatis akajei]]
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</StructureSection>
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[[Category: Chong, K T.]]
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[[Category: Hemitrygon akajei]]
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[[Category: Morimoto, H.]]
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[[Category: Large Structures]]
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[[Category: Oxygen transport]]
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[[Category: Chong KT]]
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[[Category: Morimoto H]]

Current revision

CO Form Hemoglobin from Dasyatis Akajei

PDB ID 1cg8

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