2yz8

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[[Image:2yz8.png|left|200px]]
 
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{{STRUCTURE_2yz8| PDB=2yz8 | SCENE= }}
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==Crystal structure of the 32th Ig-like domain of human obscurin (KIAA1556)==
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<StructureSection load='2yz8' size='340' side='right'caption='[[2yz8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal structure of the 32th Ig-like domain of human obscurin (KIAA1556)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2yz8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YZ8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[2yz8]] is a 1 chain structure of [[Obscurin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YZ8 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yz8 OCA], [https://pdbe.org/2yz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yz8 RCSB], [https://www.ebi.ac.uk/pdbsum/2yz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yz8 ProSAT], [https://www.topsan.org/Proteins/RSGI/2yz8 TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OBSCN_HUMAN OBSCN_HUMAN] Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.<ref>PMID:11448995</ref> <ref>PMID:16205939</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yz/2yz8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yz8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Obscurin|Obscurin]]
*[[Obscurin|Obscurin]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, L.]]
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[[Category: Large Structures]]
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[[Category: Chrzas, J.]]
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[[Category: Chen L]]
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[[Category: Fu, Z Q.]]
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[[Category: Chrzas J]]
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[[Category: Kishishita, S.]]
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[[Category: Fu ZQ]]
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[[Category: Nishino, A.]]
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[[Category: Kishishita S]]
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[[Category: Ohsawa, N.]]
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[[Category: Nishino A]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Ohsawa N]]
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[[Category: Saijo, S.]]
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[[Category: Saijo S]]
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[[Category: Shirouzu, M.]]
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[[Category: Shirouzu M]]
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[[Category: Wang, B C.]]
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[[Category: Wang BC]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Ig fold]]
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[[Category: Z-disk]]
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[[Category: Kiaa1556]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Obsucurin]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Structural protein]]
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Current revision

Crystal structure of the 32th Ig-like domain of human obscurin (KIAA1556)

PDB ID 2yz8

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