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1ki6

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[[Image:1ki6.png|left|200px]]
 
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{{STRUCTURE_1ki6| PDB=1ki6 | SCENE= }}
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==CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH A 5-IODOURACIL ANHYDROHEXITOL NUCLEOSIDE==
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<StructureSection load='1ki6' size='340' side='right'caption='[[1ki6]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH A 5-IODOURACIL ANHYDROHEXITOL NUCLEOSIDE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ki6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KI6 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9715911}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHU:1,5-ANHYDRO-2,3-DIDEOXY-2-(5-IODOURACIL-1-YL)-D-ABABINO-HEXITOL'>AHU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ki6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ki6 OCA], [https://pdbe.org/1ki6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ki6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ki6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ki6 ProSAT]</span></td></tr>
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[[1ki6]] is a 2 chain structure of [[Thymidine kinase]] with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI6 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/1ki6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ki6 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Thymidine kinase|Thymidine kinase]]
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*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:009715911</ref><references group="xtra"/>
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[[Category: Human alphaherpesvirus 1 strain 17]]
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[[Category: Thymidine kinase]]
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[[Category: Large Structures]]
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[[Category: Viruses]]
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[[Category: Bennett MS]]
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[[Category: Bennett, M S.]]
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[[Category: Champness JN]]
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[[Category: Champness, J N.]]
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[[Category: Herdewijn P]]
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[[Category: Herdewijn, P.]]
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[[Category: Ostrowski T]]
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[[Category: Ostrowski, T.]]
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[[Category: Sanderson MR]]
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[[Category: Sanderson, M R.]]
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[[Category: Summers WC]]
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[[Category: Summers, W C.]]
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[[Category: Wien F]]
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[[Category: Wien, F.]]
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[[Category: 5-iodouracil anhydrohexitol nucleoside]]
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[[Category: Alphaherpesvirinae]]
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[[Category: Ds-dna enveloped viruse]]
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[[Category: Herpesviridae]]
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[[Category: Phosphotransferase]]
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[[Category: Substrate analog]]
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[[Category: Thymidine kinase]]
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[[Category: Viridae]]
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Current revision

CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH A 5-IODOURACIL ANHYDROHEXITOL NUCLEOSIDE

PDB ID 1ki6

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