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1h1r
From Proteopedia
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| - | [[Image:1h1r.png|left|200px]] | ||
| - | + | ==Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086== | |
| - | + | <StructureSection load='1h1r' size='340' side='right'caption='[[1h1r]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1h1r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H1R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6CP:6-CYCLOHEXYLMETHOXY-2-(3-CHLOROANILINO)+PURINE'>6CP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h1r OCA], [https://pdbe.org/1h1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h1r RCSB], [https://www.ebi.ac.uk/pdbsum/1h1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h1r ProSAT]</span></td></tr> |
| - | [[1h1r]] | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CCNA2_HUMAN CCNA2_HUMAN] Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/1h1r_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h1r ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Cyclin 3D structures|Cyclin 3D structures]] |
| - | *[[Cyclin|Cyclin]] | + | *[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Davies TG]] |
| - | [[Category: | + | [[Category: Endicott JA]] |
| - | [[Category: | + | [[Category: Johnson LN]] |
| - | [[Category: | + | [[Category: Noble MEM]] |
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Current revision
Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086
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