3rg9
From Proteopedia
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| - | [[Image:3rg9.png|left|200px]] | ||
| - | + | ==Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210== | |
| - | + | <StructureSection load='3rg9' size='340' side='right'caption='[[3rg9]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3rg9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_rhodesiense Trypanosoma brucei rhodesiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RG9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=WRA:6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>WRA</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rg9 OCA], [https://pdbe.org/3rg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rg9 RCSB], [https://www.ebi.ac.uk/pdbsum/3rg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rg9 ProSAT]</span></td></tr> |
| - | [[3rg9]] | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DRTS_TRYBB DRTS_TRYBB] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity). | ||
==See Also== | ==See Also== | ||
| - | *[[Dihydrofolate reductase|Dihydrofolate reductase]] | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
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| - | [[Category: | + | |
[[Category: Trypanosoma brucei rhodesiense]] | [[Category: Trypanosoma brucei rhodesiense]] | ||
| - | [[Category: Vanichtanankul | + | [[Category: Vanichtanankul J]] |
| - | [[Category: Yuthavong | + | [[Category: Yuthavong Y]] |
| - | [[Category: Yuvaniyama | + | [[Category: Yuvaniyama J]] |
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Current revision
Trypanosoma brucei dihydrofolate reductase (TbDHFR) in complex with WR99210
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