1k86

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[[Image:1k86.png|left|200px]]
 
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{{STRUCTURE_1k86| PDB=1k86 | SCENE= }}
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==Crystal structure of caspase-7==
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<StructureSection load='1k86' size='340' side='right'caption='[[1k86]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===Crystal structure of caspase-7===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1k86]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K86 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11701129}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k86 OCA], [https://pdbe.org/1k86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k86 RCSB], [https://www.ebi.ac.uk/pdbsum/1k86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k86 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1k86]] is a 2 chain structure of [[Caspase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K86 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/1k86_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k86 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Caspase|Caspase]]
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*[[Caspase 3D structures|Caspase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011701129</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Alnemri, E S.]]
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[[Category: Large Structures]]
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[[Category: Chai, J.]]
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[[Category: Alnemri ES]]
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[[Category: Shi, Y.]]
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[[Category: Chai J]]
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[[Category: Shiozaki, E.]]
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[[Category: Shi Y]]
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[[Category: Srinivasa, S M.]]
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[[Category: Shiozaki E]]
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[[Category: Wu, Q.]]
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[[Category: Srinivasa SM]]
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[[Category: Activation]]
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[[Category: Wu Q]]
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[[Category: Apoptosis]]
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[[Category: Caspase]]
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[[Category: Zymogen]]
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Current revision

Crystal structure of caspase-7

PDB ID 1k86

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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