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3tge

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[[Image:3tge.png|left|200px]]
 
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{{STRUCTURE_3tge| PDB=3tge | SCENE= }}
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==A novel series of potent and selective PDE5 inhibitor1==
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<StructureSection load='3tge' size='340' side='right'caption='[[3tge]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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===A novel series of potent and selective PDE5 inhibitor1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tge]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TGE FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21955943}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TGE:7-(6-METHOXYPYRIDIN-3-YL)-3-{[2-(MORPHOLIN-4-YL)ETHYL]AMINO}-1-(2-PROPOXYETHYL)PYRIDO[3,4-B]PYRAZIN-2(1H)-ONE'>TGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tge OCA], [https://pdbe.org/3tge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tge RCSB], [https://www.ebi.ac.uk/pdbsum/3tge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tge ProSAT]</span></td></tr>
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[[3tge]] is a 1 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGE OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021955943</ref><references group="xtra"/>
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[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Han, S.]]
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[[Category: Large Structures]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Han S]]

Current revision

A novel series of potent and selective PDE5 inhibitor1

PDB ID 3tge

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