2f9k

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[[Image:2f9k.png|left|200px]]
 
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{{STRUCTURE_2f9k| PDB=2f9k | SCENE= }}
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==Crystal structure of human FPPS in complex with Zoledronate and Zn2+==
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<StructureSection load='2f9k' size='340' side='right'caption='[[2f9k]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
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===Crystal structure of human FPPS in complex with Zoledronate and Zn2+===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2f9k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F9K FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16892359}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=ZOL:ZOLEDRONIC+ACID'>ZOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f9k OCA], [https://pdbe.org/2f9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f9k RCSB], [https://www.ebi.ac.uk/pdbsum/2f9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f9k ProSAT]</span></td></tr>
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[[2f9k]] is a 1 chain structure of [[Farnesyl diphosphate synthase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9K OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/2f9k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f9k ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]]
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*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:016892359</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bitsch, F.]]
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[[Category: Large Structures]]
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[[Category: Bourgier, E.]]
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[[Category: Bitsch F]]
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[[Category: Geiser, M.]]
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[[Category: Bourgier E]]
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[[Category: Green, J R.]]
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[[Category: Geiser M]]
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[[Category: Hemmig, R.]]
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[[Category: Green JR]]
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[[Category: Jahnke, W.]]
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[[Category: Hemmig R]]
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[[Category: Kroemer, M.]]
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[[Category: Jahnke W]]
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[[Category: Lehmann, S.]]
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[[Category: Kroemer M]]
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[[Category: Ramage, P.]]
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[[Category: Lehmann S]]
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[[Category: Rieffel, S.]]
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[[Category: Ramage P]]
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[[Category: Rondeau, J M.]]
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[[Category: Rieffel S]]
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[[Category: Strauss, A.]]
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[[Category: Rondeau J-M]]
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[[Category: Bisphosphonate inhibitor]]
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[[Category: Strauss A]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Mevalonate pathway]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human FPPS in complex with Zoledronate and Zn2+

PDB ID 2f9k

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