1bv1

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[[Image:1bv1.gif|left|200px]]<br /><applet load="1bv1" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bv1, resolution 2.0&Aring;" />
 
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'''BIRCH POLLEN ALLERGEN BET V 1'''<br />
 
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==Overview==
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==BIRCH POLLEN ALLERGEN BET V 1==
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The three-dimensional structure of the major birch pollen allergen, the 17,500 M(r) acidic protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the crystalline state by X-ray diffraction and in solution by nuclear magnetic resonance (NMR) spectroscopy. This is the first experimentally determined structure of a clinically important inhalant major allergen, estimated to cause allergy in 5-10 million individuals worldwide. The structure shows three regions on the molecular surface predicted to harbour cross-reactive B-cell epitopes which provide a structural basis for the allergic symptoms that birch pollen allergic patients show when they encounter pollens from related trees such as hazel, alder and hornbeam. The structure also shows an unusual feature, a 30 A-long forked cavity that penetrates the entire protein.
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<StructureSection load='1bv1' size='340' side='right'caption='[[1bv1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1bv1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BV1 FirstGlance]. <br>
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1BV1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BV1 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bv1 OCA], [https://pdbe.org/1bv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bv1 RCSB], [https://www.ebi.ac.uk/pdbsum/1bv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bv1 ProSAT]</span></td></tr>
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==Reference==
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</table>
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X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy., Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, Joost van Neerven RJ, Schou C, Lowenstein H, Spangfort MD, Nat Struct Biol. 1996 Dec;3(12):1040-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8946858 8946858]
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== Function ==
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[https://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN] May be a general steroid carrier protein (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bv/1bv1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bv1 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Betula pendula]]
[[Category: Betula pendula]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gajhede, M.]]
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[[Category: Gajhede M]]
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[[Category: Ipsen, H.]]
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[[Category: Ipsen H]]
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[[Category: Joostvan, R J.]]
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[[Category: Joostvan RJ]]
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[[Category: Larson, J N.]]
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[[Category: Larson JN]]
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[[Category: Lowenstein, H.]]
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[[Category: Lowenstein H]]
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[[Category: Osmark, P.]]
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[[Category: Osmark P]]
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[[Category: Poulsen, F M.]]
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[[Category: Poulsen FM]]
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[[Category: Schou, C.]]
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[[Category: Schou C]]
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[[Category: Spangfort, M D.]]
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[[Category: Spangfort MD]]
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[[Category: allergen]]
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[[Category: pathogenesis-related protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:59:22 2008''
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Current revision

BIRCH POLLEN ALLERGEN BET V 1

PDB ID 1bv1

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OCA

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