1r7i
From Proteopedia
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| - | [[Image:1r7i.png|left|200px]] | ||
| - | + | ==HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution.== | |
| - | + | <StructureSection load='1r7i' size='340' side='right'caption='[[1r7i]], [[Resolution|resolution]] 2.21Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1r7i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_mevalonii Pseudomonas mevalonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R7I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21Å</td></tr> | |
| - | == | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | [[1r7i]] is a 2 chain structure | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7i OCA], [https://pdbe.org/1r7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r7i RCSB], [https://www.ebi.ac.uk/pdbsum/1r7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r7i ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MVAA_PSEMV MVAA_PSEMV] P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r7/1r7i_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r7i ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[HMG-CoA Reductase|HMG-CoA Reductase]] | + | *[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]] |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Pseudomonas mevalonii]] | [[Category: Pseudomonas mevalonii]] | ||
| - | [[Category: Burgner | + | [[Category: Burgner JW]] |
| - | [[Category: Lawrence | + | [[Category: Lawrence CM]] |
| - | [[Category: Rodwell | + | [[Category: Rodwell VW]] |
| - | [[Category: Stauffacher | + | [[Category: Stauffacher CV]] |
| - | [[Category: Steussy | + | [[Category: Steussy CN]] |
| - | [[Category: Tabernero | + | [[Category: Tabernero L]] |
| - | [[Category: Watson | + | [[Category: Watson JM]] |
| - | + | ||
| - | + | ||
Current revision
HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution.
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