1y01

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[[Image:1y01.png|left|200px]]
 
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{{STRUCTURE_1y01| PDB=1y01 | SCENE= }}
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==Crystal structure of AHSP bound to Fe(II) alpha-hemoglobin==
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<StructureSection load='1y01' size='340' side='right'caption='[[1y01]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===Crystal structure of AHSP bound to Fe(II) alpha-hemoglobin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1y01]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y01 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15550245}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHK:6-[(CYCLOHEXYLACETYL)(2-HYDROXYETHYL)AMINO]-6-DEOXY-D-XYLO-HEXITOL'>CHK</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y01 OCA], [https://pdbe.org/1y01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y01 RCSB], [https://www.ebi.ac.uk/pdbsum/1y01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y01 ProSAT]</span></td></tr>
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[[1y01]] is a 2 chain structure of [[Hemoglobin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y01 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AHSP_HUMAN AHSP_HUMAN] Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.<ref>PMID:12066189</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y0/1y01_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y01 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Hemoglobin|Hemoglobin]]
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015550245</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Feng, L.]]
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[[Category: Large Structures]]
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[[Category: Gell, D A.]]
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[[Category: Feng L]]
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[[Category: Gow, A J.]]
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[[Category: Gell DA]]
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[[Category: Gu, L.]]
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[[Category: Gow AJ]]
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[[Category: Mackay, J P.]]
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[[Category: Gu L]]
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[[Category: Shi, Y.]]
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[[Category: Mackay JP]]
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[[Category: Weiss, M J.]]
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[[Category: Shi Y]]
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[[Category: Zhou, S.]]
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[[Category: Weiss MJ]]
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[[Category: Ahsp]]
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[[Category: Zhou S]]
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[[Category: Alpha hemoglobin]]
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[[Category: Hemoglobin oxidation and precipitation]]
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[[Category: Oxygen storage-transport complex]]
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[[Category: Recognition]]
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[[Category: Stabilization of alpha hemoglobin]]
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Current revision

Crystal structure of AHSP bound to Fe(II) alpha-hemoglobin

PDB ID 1y01

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