1sqy

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[[Image:1sqy.png|left|200px]]
 
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{{STRUCTURE_1sqy| PDB=1sqy | SCENE= }}
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==Structure of human diferric lactoferrin at 2.5A resolution using crystals grown at pH 6.5==
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<StructureSection load='1sqy' size='340' side='right'caption='[[1sqy]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Structure of human diferric lactoferrin at 2.5A resolution using crystals grown at pH 6.5===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sqy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[1sqy]] is a 1 chain structure of [[Lactoferrin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQY OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sqy OCA], [https://pdbe.org/1sqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sqy RCSB], [https://www.ebi.ac.uk/pdbsum/1sqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sqy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRFL_HUMAN TRFL_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Isoform DeltaLf: transcription factor with antiproliferative properties and inducing cell cycle arrest. Binds to DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sqy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sqy ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Lactoferrin|Lactoferrin]]
*[[Lactoferrin|Lactoferrin]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ethayathulla, A S.]]
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[[Category: Large Structures]]
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[[Category: Kaur, P.]]
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[[Category: Ethayathulla AS]]
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[[Category: Kumar, J.]]
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[[Category: Kaur P]]
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[[Category: Kumar, R Prem.]]
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[[Category: Kumar J]]
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[[Category: Sharma, S.]]
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[[Category: Prem Kumar R]]
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[[Category: Singh, N.]]
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[[Category: Sharma S]]
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[[Category: Singh, T P.]]
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[[Category: Singh N]]
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[[Category: Vikram, P.]]
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[[Category: Singh TP]]
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[[Category: Human diferric]]
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[[Category: Vikram P]]
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[[Category: Lactoferrin]]
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[[Category: Metal binding protein]]
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[[Category: Ph 6 5]]
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Current revision

Structure of human diferric lactoferrin at 2.5A resolution using crystals grown at pH 6.5

PDB ID 1sqy

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