1x3s

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[[Image:1x3s.png|left|200px]]
 
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{{STRUCTURE_1x3s| PDB=1x3s | SCENE= }}
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==Crystal structure of human Rab18 in complex with Gppnhp==
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<StructureSection load='1x3s' size='340' side='right'caption='[[1x3s]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
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===Crystal structure of human Rab18 in complex with Gppnhp===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1x3s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X3S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.32&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[1x3s]] is a 1 chain structure of [[GTP-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X3S OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x3s OCA], [https://pdbe.org/1x3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x3s RCSB], [https://www.ebi.ac.uk/pdbsum/1x3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x3s ProSAT], [https://www.topsan.org/Proteins/RSGI/1x3s TOPSAN]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RAB18_HUMAN RAB18_HUMAN] Defects in RAB18 are the cause of Warburg micro syndrome type 3 (WARBM3) [MIM:[https://omim.org/entry/614222 614222]. WARBM3 is a rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism.<ref>PMID:21473985</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/RAB18_HUMAN RAB18_HUMAN] Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.<ref>PMID:21473985</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x3/1x3s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x3s ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[GTP-binding protein|GTP-binding protein]]
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, L.]]
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[[Category: Large Structures]]
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[[Category: Kukimoto-Niino, M.]]
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[[Category: Chen L]]
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[[Category: Liu, Z J.]]
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[[Category: Kukimoto-Niino M]]
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[[Category: Murayama, K.]]
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[[Category: Liu ZJ]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Murayama K]]
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[[Category: Shirouzu, M.]]
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[[Category: Shirouzu M]]
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[[Category: Wang, B C.]]
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[[Category: Wang BC]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Endocytosis-exocytosis complex]]
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[[Category: Gnp]]
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[[Category: Gtpase]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rab]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of human Rab18 in complex with Gppnhp

PDB ID 1x3s

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