2aoz

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[[Image:2aoz.png|left|200px]]
 
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{{STRUCTURE_2aoz| PDB=2aoz | SCENE= }}
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==Crystal structure of the myotoxin-II from Atropoides nummifer venom==
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<StructureSection load='2aoz' size='340' side='right'caption='[[2aoz]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2aoz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Metlapilcoatlus_nummifer Metlapilcoatlus nummifer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AOZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aoz OCA], [https://pdbe.org/2aoz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aoz RCSB], [https://www.ebi.ac.uk/pdbsum/2aoz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aoz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2HB_METNM PA2HB_METNM] Snake venom phospholipase A2 homolog that lacks enzymatic activity, but has myotoxic and cytolytic activities.<ref>PMID:12127577</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ao/2aoz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aoz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 angstroms resolution and the anion-binding site has been characterized.
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===Crystal structure of the myotoxin-II from Atropoides nummifer venom===
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Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom.,Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):423-6. Epub 2006 Apr 12. PMID:16682766<ref>PMID:16682766</ref>
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{{ABSTRACT_PUBMED_16682766}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2aoz" style="background-color:#fffaf0;"></div>
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[[2aoz]] is a 1 chain structure of [[Phospholipase A2]] with sequence from [http://en.wikipedia.org/wiki/Atropoides_nummifer Atropoides nummifer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AOZ OCA].
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==See Also==
==See Also==
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*[[Phospholipase A2|Phospholipase A2]]
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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*[[Phospholipase A2 homolog|Phospholipase A2 homolog]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:016682766</ref><references group="xtra"/>
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<references/>
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[[Category: Atropoides nummifer]]
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__TOC__
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[[Category: Angulo, Y.]]
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</StructureSection>
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[[Category: Arni, R K.]]
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[[Category: Large Structures]]
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[[Category: Lomonte, B.]]
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[[Category: Metlapilcoatlus nummifer]]
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[[Category: Melo, C C.]]
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[[Category: Angulo Y]]
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[[Category: Murakami, M T.]]
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[[Category: Arni RK]]
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[[Category: Atropoides nummifer]]
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[[Category: Lomonte B]]
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[[Category: Myotoxicity]]
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[[Category: Melo CC]]
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[[Category: Phospholipase a2]]
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[[Category: Murakami MT]]
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[[Category: Toxin]]
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[[Category: X-ray diffration]]
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Current revision

Crystal structure of the myotoxin-II from Atropoides nummifer venom

PDB ID 2aoz

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