1c1j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:27, 30 October 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1c1j.gif|left|200px]]<br /><applet load="1c1j" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1c1j, resolution 2.80&Aring;" />
 
-
'''STRUCTURE OF CADMIUM-SUBSTITUTED PHOSPHOLIPASE A2 FROM AGKISTRONDON HALYS PALLAS AT 2.8 ANGSTROMS RESOLUTION'''<br />
 
-
==About this Structure==
+
==STRUCTURE OF CADMIUM-SUBSTITUTED PHOSPHOLIPASE A2 FROM AGKISTRONDON HALYS PALLAS AT 2.8 ANGSTROMS RESOLUTION==
-
1C1J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys] with <scene name='pdbligand=BOG:'>BOG</scene> and <scene name='pdbligand=CD:'>CD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1J OCA].
+
<StructureSection load='1c1j' size='340' side='right'caption='[[1c1j]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
[[Category: Gloydius halys]]
+
== Structural highlights ==
-
[[Category: Phospholipase A(2)]]
+
<table><tr><td colspan='2'>[[1c1j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C1J FirstGlance]. <br>
-
[[Category: Single protein]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
[[Category: Lin, Z j.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-
[[Category: Song, S y.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1j OCA], [https://pdbe.org/1c1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c1j RCSB], [https://www.ebi.ac.uk/pdbsum/1c1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c1j ProSAT]</span></td></tr>
-
[[Category: Zhang, H l.]]
+
</table>
-
[[Category: Zhang, Y q.]]
+
== Function ==
-
[[Category: Zhou, Y.]]
+
[https://www.uniprot.org/uniprot/PA2BB_GLOHA PA2BB_GLOHA] Snake venom phospholipase A2 (PLA2) that shows potent hemolytic activity, and exhibits medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 90 nM). It is one of the few phospholipases A2 capable of hydrolyzing the phospholipids of E.coli membranes in the presence of a bactericidal/permeability-increasing protein (BPI) of neutrophils. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:10728829</ref>
-
[[Category: BOG]]
+
== Evolutionary Conservation ==
-
[[Category: CD]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: cadmium]]
+
Check<jmol>
-
[[Category: catalytic mechanism]]
+
<jmolCheckbox>
-
[[Category: phospholipase a2]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/1c1j_consurf.spt"</scriptWhenChecked>
-
[[Category: venom]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
-
[[Category: x-ray crystallography]]
+
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c1j ConSurf].
 +
<div style="clear:both"></div>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:01:22 2008''
+
==See Also==
 +
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Gloydius halys]]
 +
[[Category: Large Structures]]
 +
[[Category: Lin Z-j]]
 +
[[Category: Song S-y]]
 +
[[Category: Zhang H-l]]
 +
[[Category: Zhang Y-q]]
 +
[[Category: Zhou Y]]

Current revision

STRUCTURE OF CADMIUM-SUBSTITUTED PHOSPHOLIPASE A2 FROM AGKISTRONDON HALYS PALLAS AT 2.8 ANGSTROMS RESOLUTION

PDB ID 1c1j

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1c1j"
Personal tools