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1fv2

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[[Image:1fv2.png|left|200px]]
 
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{{STRUCTURE_1fv2| PDB=1fv2 | SCENE= }}
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==The Hc fragment of tetanus toxin complexed with an analogue of its ganglioside receptor GT1B==
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<StructureSection load='1fv2' size='340' side='right'caption='[[1fv2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===The Hc fragment of tetanus toxin complexed with an analogue of its ganglioside receptor GT1B===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FV2 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11418600}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CEQ:ETHYL-TRIMETHYL-SILANE'>CEQ</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fv2 OCA], [https://pdbe.org/1fv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fv2 RCSB], [https://www.ebi.ac.uk/pdbsum/1fv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fv2 ProSAT]</span></td></tr>
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[[1fv2]] is a 1 chain structure of [[Tetanus toxin]] with sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV2 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TETX_CLOTE TETX_CLOTE] Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/1fv2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fv2 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Tetanus toxin|Tetanus toxin]]
*[[Tetanus toxin|Tetanus toxin]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011418600</ref><references group="xtra"/>
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[[Category: Clostridium tetani]]
[[Category: Clostridium tetani]]
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[[Category: Tentoxilysin]]
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[[Category: Large Structures]]
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[[Category: Ando, H.]]
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[[Category: Ando H]]
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[[Category: Black, I.]]
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[[Category: Black I]]
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[[Category: Emsley, P.]]
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[[Category: Emsley P]]
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[[Category: Fairweather, N F.]]
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[[Category: Fairweather NF]]
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[[Category: Fotinou, C.]]
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[[Category: Fotinou C]]
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[[Category: Isaacs, N W.]]
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[[Category: Isaacs NW]]
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[[Category: Ishida, H.]]
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[[Category: Ishida H]]
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[[Category: Kiso, M.]]
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[[Category: Kiso M]]
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[[Category: Sinha, K A.]]
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[[Category: Sinha KA]]
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[[Category: Carbohydrate]]
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[[Category: Ganglioside]]
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[[Category: Multi-valent binding]]
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[[Category: Receptor]]
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[[Category: Toxin]]
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Current revision

The Hc fragment of tetanus toxin complexed with an analogue of its ganglioside receptor GT1B

PDB ID 1fv2

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OCA

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