1r15
From Proteopedia
(Difference between revisions)
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1r15.png|left|200px]] | ||
| - | + | ==Aplysia ADP ribosyl cyclase with bound nicotinamide and R5P== | |
| - | + | <StructureSection load='1r15' size='340' side='right'caption='[[1r15]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1r15]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R15 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N:ANY+5-MONOPHOSPHATE+NUCLEOTIDE'>N</scene>, <scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r15 OCA], [https://pdbe.org/1r15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r15 RCSB], [https://www.ebi.ac.uk/pdbsum/1r15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r15 ProSAT]</span></td></tr> |
| - | [[1r15]] is a 8 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NADA_APLCA NADA_APLCA] Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.<ref>PMID:11829748</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/1r15_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r15 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Aplysia californica]] | [[Category: Aplysia californica]] | ||
| - | [[Category: Graeff | + | [[Category: Large Structures]] |
| - | [[Category: Hao | + | [[Category: Graeff R]] |
| - | [[Category: Kriksunov | + | [[Category: Hao Q]] |
| - | [[Category: Lee | + | [[Category: Kriksunov IA]] |
| - | [[Category: Love | + | [[Category: Lee HC]] |
| - | [[Category: Munshi | + | [[Category: Love ML]] |
| - | [[Category: Szebenyi | + | [[Category: Munshi C]] |
| - | [[Category: Thiel | + | [[Category: Szebenyi DME]] |
| - | + | [[Category: Thiel DJ]] | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Aplysia ADP ribosyl cyclase with bound nicotinamide and R5P
| |||||||||||
Categories: Aplysia californica | Large Structures | Graeff R | Hao Q | Kriksunov IA | Lee HC | Love ML | Munshi C | Szebenyi DME | Thiel DJ
