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1tco

From Proteopedia

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[[Image:1tco.png|left|200px]]
 
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{{STRUCTURE_1tco| PDB=1tco | SCENE= }}
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==TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)==
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<StructureSection load='1tco' size='340' side='right'caption='[[1tco]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tco]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TCO FirstGlance]. <br>
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{{ABSTRACT_PUBMED_7543369}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FK5:8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN'>FK5</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tco OCA], [https://pdbe.org/1tco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tco RCSB], [https://www.ebi.ac.uk/pdbsum/1tco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tco ProSAT]</span></td></tr>
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[[1tco]] is a 3 chain structure of [[Calcineurin]] and [[FK506 binding protein]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCO OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PP2BA_BOVIN PP2BA_BOVIN] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tc/1tco_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tco ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Calcineurin|Calcineurin]]
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*[[Calcineurin 3D structures|Calcineurin 3D structures]]
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*[[FK506 binding protein|FK506 binding protein]]
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*[[FKBP 3D structures|FKBP 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:007543369</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Large Structures]]
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[[Category: Caron, P R.]]
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[[Category: Caron PR]]
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[[Category: Fitzgibbon, M J.]]
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[[Category: Fitzgibbon MJ]]
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[[Category: Fleming, M A.]]
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[[Category: Fleming MA]]
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[[Category: Griffith, J P.]]
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[[Category: Griffith JP]]
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[[Category: Hsiao, K.]]
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[[Category: Hsiao K]]
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[[Category: Kim, E E.]]
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[[Category: Kim EE]]
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[[Category: Kim, J L.]]
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[[Category: Kim JL]]
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[[Category: Navia, M A.]]
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[[Category: Navia MA]]
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[[Category: Sintchak, M D.]]
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[[Category: Sintchak MD]]
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[[Category: Thomson, J A.]]
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[[Category: Thomson JA]]
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[[Category: Immunosuppressant]]
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Current revision

TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)

PDB ID 1tco

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