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2r2l

From Proteopedia

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[[Image:2r2l.png|left|200px]]
 
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{{STRUCTURE_2r2l| PDB=2r2l | SCENE= }}
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==Structure of Farnesyl Protein Transferase bound to PB-93==
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<StructureSection load='2r2l' size='340' side='right'caption='[[2r2l]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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===Structure of Farnesyl Protein Transferase bound to PB-93===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2r2l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R2L FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17606674}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=PB9:METHYL+4-{[{(3S)-6-CYANO-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-1,2,3,4-TETRAHYDROQUINOLIN-3-YL}(PYRIDIN-2-YLSULFONYL)AMINO]METHYL}PIPERIDINE-1-CARBOXYLATE'>PB9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r2l OCA], [https://pdbe.org/2r2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r2l RCSB], [https://www.ebi.ac.uk/pdbsum/2r2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r2l ProSAT]</span></td></tr>
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[[2r2l]] is a 2 chain structure of [[Farnesyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R2L OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/2r2l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r2l ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Farnesyltransferase|Farnesyltransferase]]
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*[[Farnesyltransferase 3D structures|Farnesyltransferase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017606674</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Protein farnesyltransferase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Strickland, C O.]]
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[[Category: Strickland CO]]
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[[Category: Voorhis, W.]]
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[[Category: Voorhis W]]
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[[Category: Fpt]]
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[[Category: Malaria]]
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[[Category: Metal-binding]]
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[[Category: Phosphorylation]]
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[[Category: Prenyltransferase]]
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[[Category: Transferase]]
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Current revision

Structure of Farnesyl Protein Transferase bound to PB-93

PDB ID 2r2l

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