3fb2

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[[Image:3fb2.png|left|200px]]
 
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{{STRUCTURE_3fb2| PDB=3fb2 | SCENE= }}
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==Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.==
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<StructureSection load='3fb2' size='340' side='right'caption='[[3fb2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3fb2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FB2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[3fb2]] is a 2 chain structure of [[Spectrin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB2 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb2 OCA], [https://pdbe.org/3fb2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fb2 RCSB], [https://www.ebi.ac.uk/pdbsum/3fb2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fb2 ProSAT], [https://www.topsan.org/Proteins/NESGC/3fb2 TOPSAN]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SPTN1_HUMAN SPTN1_HUMAN] West syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/SPTN1_HUMAN SPTN1_HUMAN] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
==See Also==
==See Also==
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*[[Spectrin|Spectrin]]
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*[[Spectrin 3D structures|Spectrin 3D structures]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Ciccosanti, C.]]
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[[Category: Acton TB]]
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[[Category: Foote, E L.]]
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[[Category: Ciccosanti C]]
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[[Category: Hunt, J F.]]
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[[Category: Foote EL]]
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[[Category: Janjua, H.]]
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[[Category: Hunt JF]]
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[[Category: Montelione, G T.]]
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[[Category: Janjua H]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Seetharaman, J.]]
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[[Category: Seetharaman J]]
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[[Category: Shastry, R.]]
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[[Category: Shastry R]]
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[[Category: Su, M.]]
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[[Category: Su M]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Vorobiev, S M.]]
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[[Category: Vorobiev SM]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Actin capping]]
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[[Category: Actin-binding]]
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[[Category: Brain spectrin]]
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[[Category: Calmodulin-binding]]
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[[Category: Cytoskeleton]]
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[[Category: Fordrin alpha chain]]
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[[Category: Hr5563a]]
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[[Category: Nesg]]
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[[Category: Non-erythroid alpha chain alpha-ii spectrin]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Phosphoprotein]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Sh3 domain]]
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[[Category: Spectrin alpha chain]]
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[[Category: Spta2_human]]
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[[Category: Sptan1]]
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[[Category: Structural genomic]]
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[[Category: Structural protein]]
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Current revision

Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.

PDB ID 3fb2

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