1c5g

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[[Image:1c5g.gif|left|200px]]<br /><applet load="1c5g" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1c5g, resolution 2.60&Aring;" />
 
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'''PLASMINOGEN ACTIVATOR INHIBITOR-1'''<br />
 
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==Disease==
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==PLASMINOGEN ACTIVATOR INHIBITOR-1==
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Known diseases associated with this structure: Hemorrhagic diathesis due to PAI1 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=173360 173360]], Thrombophilia due to excessive plasminogen activator inhibitor OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=173360 173360]]
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<StructureSection load='1c5g' size='340' side='right'caption='[[1c5g]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1c5g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C5G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5g OCA], [https://pdbe.org/1c5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c5g RCSB], [https://www.ebi.ac.uk/pdbsum/1c5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c5g ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:[https://omim.org/entry/613329 613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.<ref>PMID:9207454</ref> Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.
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== Function ==
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[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.<ref>PMID:15853774</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/1c5g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c5g ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1C5G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5G OCA].
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*[[Plasminogen activator inhibitor|Plasminogen activator inhibitor]]
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== References ==
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==Reference==
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<references/>
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Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition., Tucker HM, Mottonen J, Goldsmith EJ, Gerard RD, Nat Struct Biol. 1995 Jun;2(6):442-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7664104 7664104]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Goldsmith, E J.]]
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[[Category: Goldsmith EJ]]
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[[Category: 3d-structure]]
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[[Category: blood clotting]]
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[[Category: glycoprotein]]
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[[Category: plasma]]
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[[Category: plasminogen activation]]
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[[Category: polymorphism]]
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[[Category: serine protease inhibitor]]
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[[Category: serpin]]
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[[Category: signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:02:35 2008''
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Current revision

PLASMINOGEN ACTIVATOR INHIBITOR-1

PDB ID 1c5g

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