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1m5k

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[[Image:1m5k.png|left|200px]]
 
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{{STRUCTURE_1m5k| PDB=1m5k | SCENE= }}
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==Crystal structure of a hairpin ribozyme in the catalytically-active conformation==
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<StructureSection load='1m5k' size='340' side='right'caption='[[1m5k]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Crystal structure of a hairpin ribozyme in the catalytically-active conformation===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1m5k]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hp6 1hp6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M5K FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11298439}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2M:2-O-METHYLADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>A2M</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=IU:5-IODOURIDINE-5-MONOPHOSPHATE'>IU</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m5k OCA], [https://pdbe.org/1m5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m5k RCSB], [https://www.ebi.ac.uk/pdbsum/1m5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m5k ProSAT]</span></td></tr>
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[[1m5k]] is a 6 chain structure of [[Nucleoprotein]] and [[Ribozyme]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hp6 1hp6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M5K OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m5/1m5k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m5k ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Nucleoprotein|Nucleoprotein]]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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*[[Ribozyme|Ribozyme]]
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*[[Ribozyme 3D structures|Ribozyme 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011298439</ref><ref group="xtra">PMID:012376595</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Amare, A R.Ferre-D.]]
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[[Category: Large Structures]]
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[[Category: Rupert, P B.]]
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[[Category: Ferre-D'Amare AR]]
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[[Category: Catalytic rna]]
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[[Category: Rupert PB]]
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[[Category: Hairpin ribozyme]]
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[[Category: Substrate inhibitor strand]]
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[[Category: Translation-rna complex]]
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[[Category: U1a rna binding protein docked conformation]]
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Current revision

Crystal structure of a hairpin ribozyme in the catalytically-active conformation

PDB ID 1m5k

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