3dve

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[[Image:3dve.png|left|200px]]
 
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{{STRUCTURE_3dve| PDB=3dve | SCENE= }}
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==Crystal Structure of Ca2+/CaM-CaV2.2 IQ domain complex==
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<StructureSection load='3dve' size='340' side='right'caption='[[3dve]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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===Crystal Structure of Ca2+/CaM-CaV2.2 IQ domain complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3dve]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DVE FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18940602}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dve OCA], [https://pdbe.org/3dve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dve RCSB], [https://www.ebi.ac.uk/pdbsum/3dve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dve ProSAT]</span></td></tr>
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[[3dve]] is a 2 chain structure of [[Calmodulin]], [[Ion channels]] and [[Ion channels (Part II)]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DVE OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dv/3dve_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dve ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Calmodulin|Calmodulin]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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*[[Ion channels|Ion channels]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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*[[Ion channels (Part II)|Ion channels (Part II)]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:018940602</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Cooley, E S.]]
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[[Category: Cooley ES]]
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[[Category: Fujiwara, Y.]]
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[[Category: Fujiwara Y]]
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[[Category: Kim, E Y.]]
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[[Category: Kim EY]]
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[[Category: Minor, D L.]]
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[[Category: Minor DL]]
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[[Category: Petegem, F Van.]]
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[[Category: Rumpf CH]]
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[[Category: Rumpf, C H.]]
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[[Category: Van Petegem F]]
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[[Category: Calcium channel]]
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[[Category: Calcium-dependent]]
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[[Category: Calmodulin]]
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[[Category: Facilitation]]
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[[Category: Inactivation]]
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[[Category: Iq domain]]
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[[Category: Membrane protein]]
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[[Category: Voltage-gated]]
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Current revision

Crystal Structure of Ca2+/CaM-CaV2.2 IQ domain complex

PDB ID 3dve

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