1pja

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[[Image:1pja.png|left|200px]]
 
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{{STRUCTURE_1pja| PDB=1pja | SCENE= }}
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==The crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two lysosomal thioesterases (PPT1 and PPT2)==
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<StructureSection load='1pja' size='340' side='right'caption='[[1pja]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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===The crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two lysosomal thioesterases (PPT1 and PPT2)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pja]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PJA FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12855696}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pja OCA], [https://pdbe.org/1pja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pja RCSB], [https://www.ebi.ac.uk/pdbsum/1pja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pja ProSAT]</span></td></tr>
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[[1pja]] is a 1 chain structure of [[Thioesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJA OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPT2_HUMAN PPT2_HUMAN] Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.<ref>PMID:9341199</ref> <ref>PMID:10417332</ref> <ref>PMID:12855696</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pj/1pja_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pja ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Thioesterase|Thioesterase]]
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012855696</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Palmitoyl-protein hydrolase]]
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[[Category: Large Structures]]
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[[Category: Biehl, E R.]]
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[[Category: Biehl ER]]
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[[Category: Calero, G.]]
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[[Category: Calero G]]
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[[Category: Clardy, J.]]
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[[Category: Clardy J]]
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[[Category: Gupta, P.]]
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[[Category: Gupta P]]
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[[Category: Hofmann, S L.]]
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[[Category: Hofmann SL]]
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[[Category: Nonato, M C.]]
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[[Category: Nonato MC]]
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[[Category: Tandel, S.]]
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[[Category: Tandel S]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Lysosome]]
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Current revision

The crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two lysosomal thioesterases (PPT1 and PPT2)

PDB ID 1pja

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OCA

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