1sg0

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[[Image:1sg0.png|left|200px]]
 
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{{STRUCTURE_1sg0| PDB=1sg0 | SCENE= }}
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==Crystal structure analysis of QR2 in complex with resveratrol==
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<StructureSection load='1sg0' size='340' side='right'caption='[[1sg0]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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===Crystal structure analysis of QR2 in complex with resveratrol===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sg0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SG0 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15350128}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sg0 OCA], [https://pdbe.org/1sg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sg0 RCSB], [https://www.ebi.ac.uk/pdbsum/1sg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sg0 ProSAT]</span></td></tr>
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[[1sg0]] is a 2 chain structure of [[Quinone reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG0 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sg/1sg0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sg0 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Quinone reductase|Quinone reductase]]
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*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015350128</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boyd, M.]]
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[[Category: Large Structures]]
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[[Category: Buryanovskyy, L.]]
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[[Category: Boyd M]]
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[[Category: Fu, Y.]]
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[[Category: Buryanovskyy L]]
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[[Category: Ma, Y.]]
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[[Category: Fu Y]]
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[[Category: Tsieh, T C.]]
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[[Category: Ma Y]]
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[[Category: Wu, J M.]]
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[[Category: Tsieh TC]]
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[[Category: Zhang, Z.]]
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[[Category: Wu JM]]
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[[Category: Oxidoreductase]]
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[[Category: Zhang Z]]
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[[Category: Quinone reductase 2]]
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[[Category: Resveratrol]]
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Current revision

Crystal structure analysis of QR2 in complex with resveratrol

PDB ID 1sg0

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