3ino

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[[Image:3ino.png|left|200px]]
 
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{{STRUCTURE_3ino| PDB=3ino | SCENE= }}
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==1.95A Resolution Structure of Protective Antigen Domain 4==
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<StructureSection load='3ino' size='340' side='right'caption='[[3ino]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ino]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3INO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ino FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ino OCA], [https://pdbe.org/3ino PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ino RCSB], [https://www.ebi.ac.uk/pdbsum/3ino PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ino ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Domain 4 of the anthrax protective antigen (PA) plays a key role in cellular receptor recognition as well as in pH-dependent pore formation. We present here the 1.95 A crystal structure of domain 4, which adopts a fold that is identical to that observed in the full-length protein. We have also investigated the structural properties of the isolated domain 4 as a function of pH, as well as the pH-dependence on binding to the von Willebrand factor A domain of capillary morphogenesis protein 2 (CMG2). Our results provide evidence that the isolated domain 4 maintains structure and interactions with CMG2 at pH 5, a pH that is known to cause release of the receptor on conversion of the heptameric prepore (PA(63))(7) to a membrane-spanning pore. Our results suggest that receptor release is not driven solely by a pH-induced unfolding of domain 4.
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===1.95A Resolution Structure of Protective Antigen Domain 4===
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Domain 4 of the anthrax protective antigen maintains structure and binding to the host receptor CMG2 at low pH.,Williams AS, Lovell S, Anbanandam A, El-Chami R, Bann JG Protein Sci. 2009 Nov;18(11):2277-86. PMID:19722284<ref>PMID:19722284</ref>
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{{ABSTRACT_PUBMED_19722284}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 3ino" style="background-color:#fffaf0;"></div>
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[[3ino]] is a 2 chain structure of [[Anthrax protective antigen]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INO OCA].
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== References ==
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<references/>
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==See Also==
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__TOC__
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*[[Anthrax protective antigen|Anthrax protective antigen]]
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019722284</ref><references group="xtra"/>
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[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
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[[Category: Anbanandam, A.]]
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[[Category: Large Structures]]
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[[Category: Bann, J G.]]
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[[Category: Anbanandam A]]
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[[Category: El-Chami, R.]]
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[[Category: Bann JG]]
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[[Category: Lovell, S.]]
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[[Category: El-Chami R]]
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[[Category: Williams, A S.]]
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[[Category: Lovell S]]
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[[Category: Anthrax]]
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[[Category: Williams AS]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Domain 4]]
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[[Category: Immune system]]
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[[Category: Metal-binding]]
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[[Category: Protective antigen]]
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[[Category: Secreted]]
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[[Category: Toxin]]
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[[Category: Virulence]]
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Current revision

1.95A Resolution Structure of Protective Antigen Domain 4

PDB ID 3ino

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