2b3r

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[[Image:2b3r.png|left|200px]]
 
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{{STRUCTURE_2b3r| PDB=2b3r | SCENE= }}
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==Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2==
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<StructureSection load='2b3r' size='340' side='right'caption='[[2b3r]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2b3r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B3R FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16338929}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3r OCA], [https://pdbe.org/2b3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b3r RCSB], [https://www.ebi.ac.uk/pdbsum/2b3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b3r ProSAT]</span></td></tr>
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[[2b3r]] is a 2 chain structure of [[Phosphoinositide 3-Kinases]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3R OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P3C2A_MOUSE P3C2A_MOUSE] Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.<ref>PMID:8663140</ref> <ref>PMID:20061534</ref> <ref>PMID:20974805</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/2b3r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b3r ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phosphoinositide 3-Kinases|Phosphoinositide 3-Kinases]]
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*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016338929</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Phosphatidylinositol-4-phosphate 3-kinase]]
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[[Category: Bellamy H]]
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[[Category: Bellamy, H.]]
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[[Category: Czech MP]]
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[[Category: Czech, M P.]]
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[[Category: He D]]
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[[Category: He, D.]]
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[[Category: Kita A]]
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[[Category: Kita, A.]]
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[[Category: Komma C]]
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[[Category: Komma, C.]]
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[[Category: Liu L]]
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[[Category: Liu, L.]]
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[[Category: Miki K]]
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[[Category: Miki, K.]]
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[[Category: Song X]]
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[[Category: Song, X.]]
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[[Category: Verbasius JV]]
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[[Category: Verbasius, J V.]]
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[[Category: Zhou GW]]
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[[Category: Zhou, G W.]]
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[[Category: C2 domain]]
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[[Category: Lipid binding]]
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[[Category: Pi3-kinase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2

PDB ID 2b3r

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