1khv

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[[Image:1khv.png|left|200px]]
 
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{{STRUCTURE_1khv| PDB=1khv | SCENE= }}
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==Crystal Structure of Rabbit Hemorrhagic Disease Virus RNA-dependent RNA polymerase complexed with Lu3+==
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<StructureSection load='1khv' size='340' side='right'caption='[[1khv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal Structure of Rabbit Hemorrhagic Disease Virus RNA-dependent RNA polymerase complexed with Lu3+===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1khv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rabbit_hemorrhagic_disease_virus Rabbit hemorrhagic disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KHV FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11677245}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LU:LUTETIUM+(III)+ION'>LU</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1khv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1khv OCA], [https://pdbe.org/1khv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1khv RCSB], [https://www.ebi.ac.uk/pdbsum/1khv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1khv ProSAT]</span></td></tr>
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[[1khv]] is a 2 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Rabbit_hemorrhagic_disease_virus Rabbit hemorrhagic disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KHV OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POLG_RHDVF POLG_RHDVF] NTPase presumably plays a role in replication (By similarity).<ref>PMID:1887589</ref> <ref>PMID:15063122</ref> Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity).<ref>PMID:1887589</ref> <ref>PMID:15063122</ref> 3C-like protease processes the polyprotein: 3CLpro-RdRp (p72) is first released by autocleavage, then all other proteins are cleaved (By similarity).<ref>PMID:1887589</ref> <ref>PMID:15063122</ref> RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA codes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).<ref>PMID:1887589</ref> <ref>PMID:15063122</ref> Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).<ref>PMID:1887589</ref> <ref>PMID:15063122</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kh/1khv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1khv ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011677245</ref><references group="xtra"/>
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__TOC__
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[[Category: RNA-directed RNA polymerase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rabbit hemorrhagic disease virus]]
[[Category: Rabbit hemorrhagic disease virus]]
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[[Category: Alonso, J M.]]
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[[Category: Alonso JM]]
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[[Category: Cherney, M M.]]
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[[Category: Cherney MM]]
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[[Category: James, M N.]]
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[[Category: James MN]]
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[[Category: Machin, A.]]
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[[Category: Machin A]]
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[[Category: Ng, K K.]]
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[[Category: Ng KK]]
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[[Category: Parra, F.]]
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[[Category: Parra F]]
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[[Category: Vazquez, A L.]]
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[[Category: Vazquez AL]]
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[[Category: Rna-dependent rna polymerase]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Rabbit Hemorrhagic Disease Virus RNA-dependent RNA polymerase complexed with Lu3+

PDB ID 1khv

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