2gao

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[[Image:2gao.png|left|200px]]
 
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{{STRUCTURE_2gao| PDB=2gao | SCENE= }}
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==Crystal Structure of Human SAR1a in Complex With GDP==
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<StructureSection load='2gao' size='340' side='right'caption='[[2gao]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal Structure of Human SAR1a in Complex With GDP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2gao]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GAO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[2gao]] is a 2 chain structure of [[GTP-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GAO OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gao OCA], [https://pdbe.org/2gao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gao RCSB], [https://www.ebi.ac.uk/pdbsum/2gao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gao ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAR1A_HUMAN SAR1A_HUMAN] Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).<ref>PMID:17005010</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/2gao_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gao ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[GTP-binding protein|GTP-binding protein]]
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith C]]
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[[Category: Dimov, S.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A.]]
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[[Category: Dimov S]]
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[[Category: Park, H.]]
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[[Category: Edwards A]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Park H]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Wang, J.]]
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[[Category: Wang J]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Yaniw, D.]]
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[[Category: Yaniw D]]
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[[Category: Gdp]]
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[[Category: Gtpase]]
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[[Category: Protein transport]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal Structure of Human SAR1a in Complex With GDP

PDB ID 2gao

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