2our

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[[Image:2our.png|left|200px]]
 
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{{STRUCTURE_2our| PDB=2our | SCENE= }}
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==crystal structure of PDE10A2 mutant D674A in complex with cAMP==
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<StructureSection load='2our' size='340' side='right'caption='[[2our]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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===crystal structure of PDE10A2 mutant D674A in complex with cAMP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2our]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OUR FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17389385}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2our FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2our OCA], [https://pdbe.org/2our PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2our RCSB], [https://www.ebi.ac.uk/pdbsum/2our PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2our ProSAT]</span></td></tr>
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[[2our]] is a 2 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUR OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ou/2our_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2our ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017389385</ref><references group="xtra"/>
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__TOC__
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hou, J.]]
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[[Category: Large Structures]]
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[[Category: Liu, Y D.]]
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[[Category: Hou J]]
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[[Category: Robinson, H.]]
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[[Category: Liu YD]]
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[[Category: Wang, H C.]]
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[[Category: Robinson H]]
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[[Category: Zheng, M Y.]]
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[[Category: Wang HC]]
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[[Category: Camp]]
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[[Category: Zheng MY]]
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[[Category: Hydrolase]]
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[[Category: Pde10]]
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[[Category: Substrate specificity]]
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Current revision

crystal structure of PDE10A2 mutant D674A in complex with cAMP

PDB ID 2our

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